Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis

Whereas ribosomes efficiently catalyze peptide bond synthesis by most amino acids, the imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that the translation factor eIF5A and its bacterial ortholog EF-P bind in the E site of the ribosome where they contact the...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Shin, Byung-Sik, Katoh, Takayuki, Gutierrez, Erik, Kim, Joo-Ran, Suga, Hiroaki, Dever, Thomas E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737446/
https://ncbi.nlm.nih.gov/pubmed/28637321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx532
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