Randomized study of etirinotecan pegol versus irinotecan as second-line treatment for metastatic colorectal cancer

PURPOSE: Etirinotecan pegol (EP) is a long-acting topoisomerase-I inhibitor designed to provide sustained exposure to SN-38 (active metabolite of irinotecan). This phase II study compared EP versus irinotecan as second-line treatment for KRAS-mutant, irinotecan-naïve, metastatic colorectal cancer (m...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Lenz, Heinz-Josef, Philip, Philip, Saunders, Mark, Kolevska, Tatjana, Mukherjee, Kalyan, Samuel, Leslie, Bondarde, Shailesh, Dobbs, Tracy, Tagliaferri, Mary, Hoch, Ute, Hannah, Alison L., Berkowitz, Maurice
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863159/
https://ncbi.nlm.nih.gov/pubmed/29043412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3438-y
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