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Total Synthesis of Hinduchelins A–D, Stereochemical Revision of Hinduchelin A, and Biological Evaluation of Natural and Unnatural Analogues
Here, we report the first total synthesis of hinduchelins A–D, a family of nontoxic catechol derivatives from Streptoalloteichus hindustanus, possessing a druglike chemotype and modest iron-chelating ability. A concise synthesis was developed employing methyl 5-methyloxazole-4-carboxylate as a singl...
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| Udgivet i: | J Org Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6863084/ https://ncbi.nlm.nih.gov/pubmed/31039303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b00391 |
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