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Neurofilament Heavy Chain and Tau Protein Are Not Elevated in Cerebrospinal Fluid of Adult Patients with Spinal Muscular Atrophy during Loading with Nusinersen

Nusinersen is the first approved drug for the treatment of spinal muscular atrophy (SMA). Treatment of SMA with nusinersen is based on a fixed dosing regimen. For other motoneuron diseases, such as amyotrophic lateral sclerosis (ALS), biomarkers are available for clinical diagnostics; however, no su...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Totzeck, Andreas, Stolte, Benjamin, Kizina, Kathrin, Bolz, Saskia, Schlag, Melina, Thimm, Andreas, Kleinschnitz, Christoph, Hagenacker, Tim
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862027/
https://ncbi.nlm.nih.gov/pubmed/31671515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20215397
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