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Functional tunability from a distance: Rheostat positions influence allosteric coupling between two distant binding sites

For protein mutagenesis, a common expectation is that important positions will behave like on/off “toggle” switches (i.e., a few substitutions act like wildtype, most abolish function). However, there exists another class of important positions that manifests a wide range of functional outcomes upon...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Wu, Tiffany, Swint-Kruse, Liskin, Fenton, Aron W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861286/
https://ncbi.nlm.nih.gov/pubmed/31740686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53464-z
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