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Functional tunability from a distance: Rheostat positions influence allosteric coupling between two distant binding sites
For protein mutagenesis, a common expectation is that important positions will behave like on/off “toggle” switches (i.e., a few substitutions act like wildtype, most abolish function). However, there exists another class of important positions that manifests a wide range of functional outcomes upon...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6861286/ https://ncbi.nlm.nih.gov/pubmed/31740686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53464-z |
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