A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

Conventionally, most amino acid substitutions at “important” protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of nonconserved positions for which various substitutions produced progressive functional changes; we consider these e...

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Publicado en:J Biol Chem
Autores principales: Ruggiero, Melissa J., Malhotra, Shipra, Fenton, Aron W., Swint-Kruse, Liskin, Karanicolas, John, Hagenbuch, Bruno
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948949/
https://ncbi.nlm.nih.gov/pubmed/33168628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014889
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