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Computational predictors fail to identify amino acid substitution effects at rheostat positions
Many computational approaches exist for predicting the effects of amino acid substitutions. Here, we considered whether the protein sequence position class – rheostat or toggle – affects these predictions. The classes are defined as follows: experimentally evaluated effects of amino acid substitutio...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278360/ https://ncbi.nlm.nih.gov/pubmed/28134345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41329 |
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