Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia

Schizophrenia (SZ) is a highly heterogeneous disorder in both its symptoms and risk factors. One of the most prevalent genetic risk factors for SZ is the hemizygous microdeletion at chromosome 22q11.2 (22q11DS) that confers a 25-fold increased risk. Six of the genes directly disrupted in 22qDS encod...

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Veröffentlicht in:Transl Psychiatry
Hauptverfasser: Li, Jianping, Ryan, Sean K., Deboer, Erik, Cook, Kieona, Fitzgerald, Shane, Lachman, Herbert M., Wallace, Douglas C., Goldberg, Ethan M., Anderson, Stewart A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861238/
https://ncbi.nlm.nih.gov/pubmed/31740674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0643-y
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