RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

Hepatocyte apoptosis is intrinsically linked to chronic liver disease and hepatocarcinogenesis. Conversely, necroptosis of hepatocytes and other liver cell types and its relevance for liver disease is debated. Using liver parenchymal cell (LPC)-specific TGF-beta-activated kinase 1 (TAK1)-deficient (...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Krishna-Subramanian, Santosh, Singer, Stephan, Armaka, Marietta, Banales, Jesus M., Holzer, Kerstin, Schirmacher, Peter, Walczak, Henning, Kollias, George, Pasparakis, Manolis, Kondylis, Vangelis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861136/
https://ncbi.nlm.nih.gov/pubmed/30988397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0330-9
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