In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

Recent evidence has determined that the conserved X chromosome mega-structures controlled by the Firre and Dxz4 loci are not required for X chromosome inactivation (XCI) in cell lines. Here, we examined the in vivo contribution of these loci by generating mice carrying a single or double deletion of...

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Bibliographic Details
Published in:eLife
Main Authors: Andergassen, Daniel, Smith, Zachary D, Lewandowski, Jordan P, Gerhardinger, Chiara, Meissner, Alexander, Rinn, John L
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Chromosomes and Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6860989/
https://ncbi.nlm.nih.gov/pubmed/31738164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47214
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