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Coding regions affect mRNA stability in human cells

A new paradigm has emerged that coding regions can regulate mRNA stability in model organisms. Here, due to differences in cognate tRNA abundance, synonymous codons are translated at different speeds, and slow codons then stimulate mRNA decay. To ask if this phenomenon also occurs in humans, we isol...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Narula, Ashrut, Ellis, James, Taliaferro, J. Matthew, Rissland, Olivia S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859850/
https://ncbi.nlm.nih.gov/pubmed/31527111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073239.119
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