The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

BACKGROUND: The apolipoprotein E ε4 gene variant (APOEε4) confers considerable risk for dementia and affects neuroinflammation, brain metabolism, and synaptic function. The kynurenine pathway (KP) gives rise to neuroactive metabolites, which have inflammatory, redox, and excitotoxic effects in the b...

詳細記述

保存先:
書誌詳細
出版年:Int J Tryptophan Res
主要な著者: Ervik, Arne Olav, Solvang, Stein-Erik Hafstad, Nordrehaug, Jan Erik, Ueland, Per Magne, Midttun, Øivind, Hildre, Audun, McCann, Adrian, Nygård, Ottar, Aarsland, Dag, Giil, Lasse Melvaer
フォーマット: Artigo
言語:Inglês
出版事項: SAGE Publications 2019
主題:
Original Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859685/
https://ncbi.nlm.nih.gov/pubmed/31798303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1178646919885637
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