The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

BACKGROUND: The apolipoprotein E ε4 gene variant (APOEε4) confers considerable risk for dementia and affects neuroinflammation, brain metabolism, and synaptic function. The kynurenine pathway (KP) gives rise to neuroactive metabolites, which have inflammatory, redox, and excitotoxic effects in the b...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Tryptophan Res
Main Authors: Ervik, Arne Olav, Solvang, Stein-Erik Hafstad, Nordrehaug, Jan Erik, Ueland, Per Magne, Midttun, Øivind, Hildre, Audun, McCann, Adrian, Nygård, Ottar, Aarsland, Dag, Giil, Lasse Melvaer
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2019
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859685/
https://ncbi.nlm.nih.gov/pubmed/31798303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1178646919885637
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