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Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics
Many multidomain proteins contain disordered linkers that regulate interdomain contacts, and thus the effective concentrations that govern intramolecular reactions. Effective concentrations are rarely measured experimentally, and therefore little is known about how they relate to linker architecture...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6859346/ https://ncbi.nlm.nih.gov/pubmed/31659043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904813116 |
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