A systems view of spliceosomal assembly and branchpoints with iCLIP

Studies of spliceosomal interactions are challenging due to their dynamic nature. Here we employed spliceosome iCLIP, which immunoprecipitates SmB along with snRNPs and auxiliary RNA binding proteins (RBPs), to map spliceosome engagement with pre-mRNAs in human cell lines. This revealed seven peaks...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Briese, Michael, Haberman, Nejc, Sibley, Christopher R., Faraway, Rupert, Elser, Andrea S., Chakrabarti, Anob M., Wang, Zhen, König, Julian, Perera, David, Wickramasinghe, Vihandha O., Venkitaraman, Ashok R., Luscombe, Nicholas M., Saieva, Luciano, Pellizzoni, Livio, Smith, Christopher W.J., Curk, Tomaž, Ule, Jernej
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859068/
https://ncbi.nlm.nih.gov/pubmed/31570875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0300-4
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