PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer

PURPOSE: In this study we addressed the underlying mechanisms for the association between enzalutamide treatment and NEPC, and the critical involvement of MYCN, and loss of RB1 function in NED of prostatic epithelial cells, and the development of NEPC. We further sought to determine whether PARP inh...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Liu, Bo, Li, Likun, Yang, Guang, Geng, Chuandong, Luo, Yong, Wu, Wenhui, Manyam, Ganiraju C., Korentzelos, Dimitrios, Park, Sanghee, Tang, Zhe, Wu, Cheng, Dong, Zhenyang, Sigouros, Michael, Sboner, Andrea, Beltran, Himisha, Chen, Yu, Corn, Paul G., Tetzlaff, Michael T., Troncoso, Patricia, Broom, Bradley, Thompson, Timothy C.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858969/
https://ncbi.nlm.nih.gov/pubmed/31439587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0317
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