PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer

PURPOSE: In this study we addressed the underlying mechanisms for the association between enzalutamide treatment and NEPC, and the critical involvement of MYCN, and loss of RB1 function in NED of prostatic epithelial cells, and the development of NEPC. We further sought to determine whether PARP inh...

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Published in:Clin Cancer Res
Main Authors: Liu, Bo, Li, Likun, Yang, Guang, Geng, Chuandong, Luo, Yong, Wu, Wenhui, Manyam, Ganiraju C., Korentzelos, Dimitrios, Park, Sanghee, Tang, Zhe, Wu, Cheng, Dong, Zhenyang, Sigouros, Michael, Sboner, Andrea, Beltran, Himisha, Chen, Yu, Corn, Paul G., Tetzlaff, Michael T., Troncoso, Patricia, Broom, Bradley, Thompson, Timothy C.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858969/
https://ncbi.nlm.nih.gov/pubmed/31439587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0317
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