Structure of the Fanconi anemia monoubiquitin ligase complex

The Fanconi Anemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress(1,2). Genetic inactivation of this pathway impairs development, prevents blood production and promotes cancer(1,3). The key molecular step in the FA pat...

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Udgivet i:Nature
Main Authors: Shakeel, Shabih, Rajendra, Eeson, Alcón, Pablo, O’Reilly, Francis, Chorev, Dror S., Maslen, Sarah, Degliesposti, Gianluca, Russo, Christopher J., He, Shaoda, Hill, Chris H., Skehel, J. Mark, Scheres, Sjors H.W., Patel, Ketan J., Rappsilber, Juri, Robinson, Carol V., Passmore, Lori A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858856/
https://ncbi.nlm.nih.gov/pubmed/31666700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1703-4
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