The density and spatial tissue distribution of CD8(+) and CD163(+) immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

BACKGROUND: Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to treatment clinical benefit, the pre-existing level of immunity at tumor site may provide biomarkers of disease o...

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Publicat a:J Immunother Cancer
Autors principals: Massi, Daniela, Rulli, Eliana, Cossa, Mara, Valeri, Barbara, Rodolfo, Monica, Merelli, Barbara, De Logu, Francesco, Nassini, Romina, Del Vecchio, Michele, Di Guardo, Lorenza, De Penni, Roberta, Guida, Michele, Sileni, Vanna Chiarion, Di Giacomo, Anna Maria, Tucci, Marco, Occelli, Marcella, Portelli, Francesca, Vallacchi, Viviana, Consoli, Francesca, Quaglino, Pietro, Queirolo, Paola, Baroni, Gianna, Carnevale-Schianca, Fabrizio, Cattaneo, Laura, Minisini, Alessandro, Palmieri, Giuseppe, Rivoltini, Licia, Mandalà, Mario
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858711/
https://ncbi.nlm.nih.gov/pubmed/31730502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0797-4
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