The density and spatial tissue distribution of CD8(+) and CD163(+) immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

BACKGROUND: Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to treatment clinical benefit, the pre-existing level of immunity at tumor site may provide biomarkers of disease o...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Massi, Daniela, Rulli, Eliana, Cossa, Mara, Valeri, Barbara, Rodolfo, Monica, Merelli, Barbara, De Logu, Francesco, Nassini, Romina, Del Vecchio, Michele, Di Guardo, Lorenza, De Penni, Roberta, Guida, Michele, Sileni, Vanna Chiarion, Di Giacomo, Anna Maria, Tucci, Marco, Occelli, Marcella, Portelli, Francesca, Vallacchi, Viviana, Consoli, Francesca, Quaglino, Pietro, Queirolo, Paola, Baroni, Gianna, Carnevale-Schianca, Fabrizio, Cattaneo, Laura, Minisini, Alessandro, Palmieri, Giuseppe, Rivoltini, Licia, Mandalà, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858711/
https://ncbi.nlm.nih.gov/pubmed/31730502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0797-4
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