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Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics
We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally-invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery and implantation of invasive fiber-optic cabl...
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| Publicado no: | Nat Methods |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858556/ https://ncbi.nlm.nih.gov/pubmed/31611694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0583-8 |
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