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Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization

There is growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in sensing and regulating cellular response to diverse external signals. A MP must be expressed, correctly inserted and folded in a lipid bilayer, and trafficked to the proper cellular location...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Bedbrook, Claire N., Yang, Kevin K., Rice, Austin J., Gradinaru, Viviana, Arnold, Frances H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695628/
https://ncbi.nlm.nih.gov/pubmed/29059183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005786
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