PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis

AXL is expressed in many types of cancer and promotes cancer cell survival, metastasis and drug resistance. Here, we focus on identifying modulators that regulate AXL at the mRNA level. We have previously observed that the AXL promoter activity is inversely correlated with the AXL expression levels,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cho, Chun-Yu, Chung, Shih-Ying, Lin, Shankung, Huang, Jhy-Shrian, Chen, Yen-Lin, Jiang, Shih-Sheng, Cheng, Li-Chun, Kuo, Tsu-Hsiang, Lay, Jong-Ding, Yang, Ya-Yu, Lai, Gi-Ming, Chuang, Shuang-En
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858377/
https://ncbi.nlm.nih.gov/pubmed/31729427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53097-2
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