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Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective
[Image: see text] The spread of antibiotic resistance is one of the most serious global public-health problems. Here we show that a particular class of homomers with binding sites spanning multiple protein chains is particularly suitable for targeting by broad-spectrum antibacterial agents because d...
Guardat en:
| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2019
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858282/ https://ncbi.nlm.nih.gov/pubmed/31188598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00220 |
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