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Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology
It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes. We show that h...
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| Izdano u: | Cell Rep |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cell Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873459/ https://ncbi.nlm.nih.gov/pubmed/29562182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.085 |
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