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Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology

It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes. We show that h...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Abrusán, György, Marsh, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873459/
https://ncbi.nlm.nih.gov/pubmed/29562182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.085
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