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Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

The structure of ligand-binding sites has been shown to profoundly influence the evolution of function in homomeric protein complexes. Complexes with multichain binding sites (MBSs) have more conserved quaternary structure, more similar binding sites and ligands between homologs, and evolve new func...

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Detalles Bibliográficos
Publicado en:Mol Biol Evol
Autores principales: Abrusán, György, Marsh, Joseph A
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657754/
https://ncbi.nlm.nih.gov/pubmed/31004156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msz093
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