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Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes

The structure of ligand-binding sites has been shown to profoundly influence the evolution of function in homomeric protein complexes. Complexes with multichain binding sites (MBSs) have more conserved quaternary structure, more similar binding sites and ligands between homologs, and evolve new func...

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Bibliografski detalji
Izdano u:Mol Biol Evol
Glavni autori: Abrusán, György, Marsh, Joseph A
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657754/
https://ncbi.nlm.nih.gov/pubmed/31004156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msz093
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