RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

Necroptosis is a form of programmed cell death that is defined by activation of the kinase RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 activation can also promote immune responses via production of cytokines and chemokines. How active cytokine production is coordi...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Orozco, Susana L., Daniels, Brian P., Yatim, Nader, Messmer, Michelle N., Quarato, Giovanni, Chen-Harris, Haiyin, Cullen, Sean P., Snyder, Annelise G., Ralli-Jain, Pooja, Frase, Sharon, Tait, Stephen W.G., Green, Douglas R., Albert, Matthew L., Oberst, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857709/
https://ncbi.nlm.nih.gov/pubmed/31461645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.077
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