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A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates
When designing prodrugs, choosing an appropriate linker is the key to achieving efficient, controlled drug delivery. Herein, we report the use of a photocaged C4′-oxidized abasic site (PC4AP) as a light-responsive, self-immolative linker. Any amine- or hydroxyl-bearing drug can be loaded onto the li...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6857671/ https://ncbi.nlm.nih.gov/pubmed/31762977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc03016f |
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