N-cadherin stabilises neural identity by dampening anti-neural signals

A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the acquisition of N-cadherin stabilises neural identity by dampening anti-neural signals. We use qua...

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Bibliographic Details
Published in:Development
Main Authors: Punovuori, Karolina, Migueles, Rosa P., Malaguti, Mattias, Blin, Guillaume, Macleod, Kenneth G., Carragher, Neil O., Pieters, Tim, van Roy, Frans, Stemmler, Marc P., Lowell, Sally
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
Subjects:
Stem Cells and Regeneration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857587/
https://ncbi.nlm.nih.gov/pubmed/31601548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.183269
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