GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126

Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GAT...

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Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Mahamud, Md. Riaj, Geng, Xin, Ho, Yen-Chun, Cha, Boksik, Kim, Yuenhee, Ma, Jing, Chen, Lijuan, Myers, Greggory, Camper, Sally, Mustacich, Debbie, Witte, Marlys, Choi, Dongwon, Hong, Young-Kwon, Chen, Hong, Varshney, Gaurav, Engel, James Douglas, Wang, Shusheng, Kim, Tae-Hoon, Lim, Kim-Chew, Srinivasan, R. Sathish
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857586/
https://ncbi.nlm.nih.gov/pubmed/31582413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.184218
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