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GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126

Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GAT...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Development
Main Authors: Mahamud, Md. Riaj, Geng, Xin, Ho, Yen-Chun, Cha, Boksik, Kim, Yuenhee, Ma, Jing, Chen, Lijuan, Myers, Greggory, Camper, Sally, Mustacich, Debbie, Witte, Marlys, Choi, Dongwon, Hong, Young-Kwon, Chen, Hong, Varshney, Gaurav, Engel, James Douglas, Wang, Shusheng, Kim, Tae-Hoon, Lim, Kim-Chew, Srinivasan, R. Sathish
פורמט: Artigo
שפה:Inglês
יצא לאור: The Company of Biologists Ltd 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857586/
https://ncbi.nlm.nih.gov/pubmed/31582413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.184218
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