Retroelement Insertion in a CRISPR/Cas9 Editing Site in the Early Embryo Intensifies Genetic Mosaicism

Continued CRISPR/Cas9-mediated editing activity that allows differential and asynchronous modification of alleles in successive cell generations expands allelic complexity. To understand the earliest events during CRISPR/Cas9 editing and the allelic selection among the progeny of subsequent cell div...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Jeon, Jeehyun, Park, Jung Sun, Min, Byungkuk, Chung, Sun-Ku, Kim, Min Kyu, Kang, Yong-Kook
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857330/
https://ncbi.nlm.nih.gov/pubmed/31781562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00273
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