Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

BACKGROUND: A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how they influence results in large cohort studies. RESULTS: We tested the associa...

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Bibliographic Details
Published in:Genome Biol
Main Authors: van Rooij, Jeroen, Mandaviya, Pooja R., Claringbould, Annique, Felix, Janine F., van Dongen, Jenny, Jansen, Rick, Franke, Lude, ’t Hoen, Peter A. C., Heijmans, Bas, van Meurs, Joyce B. J.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857161/
https://ncbi.nlm.nih.gov/pubmed/31727104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1878-x
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