Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

BACKGROUND: A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how they influence results in large cohort studies. RESULTS: We tested the associa...

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Udgivet i:Genome Biol
Main Authors: van Rooij, Jeroen, Mandaviya, Pooja R., Claringbould, Annique, Felix, Janine F., van Dongen, Jenny, Jansen, Rick, Franke, Lude, ’t Hoen, Peter A. C., Heijmans, Bas, van Meurs, Joyce B. J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857161/
https://ncbi.nlm.nih.gov/pubmed/31727104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1878-x
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