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Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case

Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib demonstrates a long terminal half‐life and accumulates in adipose...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Johns, Douglas G., Wang, Sheng‐Ping, Rosa, Raymond, Hubert, James, Xu, Suoyu, Chen, Ying, Bateman, Thomas, Blaustein, Robert O.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857080/
https://ncbi.nlm.nih.gov/pubmed/31832204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.543
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