Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects

AIMS: Anacetrapib is an orally active and potent inhibitor of CETP in development for the treatment of dyslipidaemia. These studies endeavoured to establish the safety, tolerability, pharmacokinetics and pharmacodynamics of rising single doses of anacetrapib, administered in fasted or fed conditions...

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Autori principali: Krishna, Rajesh, Garg, Amit, Panebianco, Deborah, Cote, Josee, Bergman, Arthur J, Van Hoydonck, Pascale, Laethem, Tine, Van Dyck, Kristien, Chen, Jingjing, Chavez-Eng, Cynthia, Archer, Laura, Lutz, Ryan, Hilliard, Deborah, Snyder, Karen, Jin, Bo, Van Bortel, Luc, Lasseter, Kenneth C, Al-Huniti, Nidal, Dykstra, Kevin, Gottesdiener, Keith, Wagner, John A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2009
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780279/
https://ncbi.nlm.nih.gov/pubmed/19843057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03465.x
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