Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects

AIMS: Anacetrapib is an orally active and potent inhibitor of CETP in development for the treatment of dyslipidaemia. These studies endeavoured to establish the safety, tolerability, pharmacokinetics and pharmacodynamics of rising single doses of anacetrapib, administered in fasted or fed conditions...

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Detalhes bibliográficos
Main Authors: Krishna, Rajesh, Garg, Amit, Panebianco, Deborah, Cote, Josee, Bergman, Arthur J, Van Hoydonck, Pascale, Laethem, Tine, Van Dyck, Kristien, Chen, Jingjing, Chavez-Eng, Cynthia, Archer, Laura, Lutz, Ryan, Hilliard, Deborah, Snyder, Karen, Jin, Bo, Van Bortel, Luc, Lasseter, Kenneth C, Al-Huniti, Nidal, Dykstra, Kevin, Gottesdiener, Keith, Wagner, John A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780279/
https://ncbi.nlm.nih.gov/pubmed/19843057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03465.x
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