Pten loss in Lgr5(+) hair follicle stem cells promotes SCC development

Accumulating data support that tissue stem cells give rise to cancer cells. Hair follicle stem cells (HFSCs) undergo cyclic quiescence and activation and may sever as the origin of cutaneous squamous cell carcinoma (SCC). Pten is a tumor suppressor gene that is frequently mutated in hereditary cance...

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Bibliographic Details
Published in:Theranostics
Main Authors: Chen, Haiyan, Wang, Xusheng, Chen, Yu, Han, Jimin, Kong, Deqiang, Zhu, Meishu, Fu, Xiaobing, Wu, Yaojiong
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857063/
https://ncbi.nlm.nih.gov/pubmed/31754399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35467
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