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Pten loss in Lgr5(+) hair follicle stem cells promotes SCC development
Accumulating data support that tissue stem cells give rise to cancer cells. Hair follicle stem cells (HFSCs) undergo cyclic quiescence and activation and may sever as the origin of cutaneous squamous cell carcinoma (SCC). Pten is a tumor suppressor gene that is frequently mutated in hereditary cance...
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| Veröffentlicht in: | Theranostics |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Ivyspring International Publisher
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6857063/ https://ncbi.nlm.nih.gov/pubmed/31754399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35467 |
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