Pten loss in Lgr5(+) hair follicle stem cells promotes SCC development

Accumulating data support that tissue stem cells give rise to cancer cells. Hair follicle stem cells (HFSCs) undergo cyclic quiescence and activation and may sever as the origin of cutaneous squamous cell carcinoma (SCC). Pten is a tumor suppressor gene that is frequently mutated in hereditary cance...

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Vydáno v:Theranostics
Hlavní autoři: Chen, Haiyan, Wang, Xusheng, Chen, Yu, Han, Jimin, Kong, Deqiang, Zhu, Meishu, Fu, Xiaobing, Wu, Yaojiong
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857063/
https://ncbi.nlm.nih.gov/pubmed/31754399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35467
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