Macrophages induce AKT/β-catenin-dependent Lgr5(+) stem cell activation and hair follicle regeneration through TNF

Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the wound and de novo HF regeneration, mostly through...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Wang, Xusheng, Chen, Haiyan, Tian, Ruiyun, Zhang, Yiling, Drutskaya, Marina S., Wang, Chengmei, Ge, Jianfeng, Fan, Zhimeng, Kong, Deqiang, Wang, Xiaoxiao, Cai, Ting, Zhou, Ying, Wang, Jingwen, Wang, Jinmei, Wang, Shan, Qin, Zhihai, Jia, Huanhuan, Wu, Yue, Liu, Jia, Nedospasov, Sergei A., Tredget, Edward E., Lin, Mei, Liu, Jianjun, Jiang, Yuyang, Wu, Yaojiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378973/
https://ncbi.nlm.nih.gov/pubmed/28345588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14091
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