Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway

Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as a sensitizer for oxaliplatin (L-OHP) chemoresistant CRC cells. The aim of this study was to explore the...

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Detalhes bibliográficos
Publicado no:J Cancer
Main Authors: Liang, Yu, Zhu, Danxi, Zhu, Liming, Hou, Yichao, Hou, Lidan, Huang, Xin, Li, Linjing, Wang, Yu, Li, Lei, Zou, Huimin, Wu, Tianqi, Yao, Mengfei, Wang, Jianhua, Meng, Xiangjun
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856576/
https://ncbi.nlm.nih.gov/pubmed/31762813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.34650
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