Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway

Exploring novel anticancer drugs to optimize the efficacy may provide a benefit for the treatment of colorectal cancer (CRC). Disulfiram (DSF), as an antialcoholism drug, is metabolized into diethyldithiocarbamate-copper complex (CuET) in vivo, which has been reported to exert the anticancer effects...

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Publicat a:Oncogenesis
Autors principals: Huang, Xin, Hou, Yichao, Weng, Xiaoling, Pang, Wenjing, Hou, Lidan, Liang, Yu, Wang, Yu, Du, Leilei, Wu, Tianqi, Yao, Mengfei, Wang, Jianhua, Meng, Xiangjun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794448/
https://ncbi.nlm.nih.gov/pubmed/33419984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00295-7
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