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Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids

Cystic fibrosis (CF) is a life-shortening genetic disease caused by mutations of CFTR, the gene encoding cystic fibrosis transmembrane conductance regulator. Despite considerable progress in CF therapies, targeting specific CFTR genotypes based on small molecules has been hindered because of the sub...

詳細記述

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書誌詳細
出版年:Drug Discov Today
主要な著者: Chen, Kevin G., Zhong, Pingyu, Zheng, Wei, Beekman, Jeffrey M.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856431/
https://ncbi.nlm.nih.gov/pubmed/31173911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2019.05.029
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