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Lamellipodium tip actin barbed ends serve as a force sensor

Cells change direction of migration by sensing rigidity of environment and traction force, yet its underlying mechanism is unclear. Here we show that tip actin barbed ends serve as an active ‘force sensor’ at the leading edge. We established a method to visualize intracellular single-molecule fluore...

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Détails bibliographiques
Publié dans:Genes Cells
Auteurs principaux: Koseki, Kazuma, Taniguchi, Daisuke, Yamashiro, Sawako, Mizuno, Hiroaki, Vavylonis, Dimitrios, Watanabe, Naoki
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856401/
https://ncbi.nlm.nih.gov/pubmed/31514256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gtc.12720
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