High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A

Non-steroidal anti-inflammatory drugs (NSAIDs) cause damage in the small intestine in a bacteria-dependent manner. As high-fat diet (HFD) is a potent inducer of gut dysbiosis, we investigated the effects of HFD on bacterial flora in the small intestine and NSAID-induced enteropathy. 16S rRNA gene an...

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Vydáno v:Sci Rep
Hlavní autoři: Sugimura, Naoki, Otani, Koji, Watanabe, Toshio, Nakatsu, Geicho, Shimada, Sunao, Fujimoto, Kosuke, Nadatani, Yuji, Hosomi, Shuhei, Tanaka, Fumio, Kamata, Noriko, Taira, Koichi, Nagami, Yasuaki, Tanigawa, Tetsuya, Uematsu, Satoshi, Fujiwara, Yasuhiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856170/
https://ncbi.nlm.nih.gov/pubmed/31727909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52980-2
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