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Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease

The accumulation of amyloid-β protein (Aβ) in brain is linked to the early pathogenesis of Alzheimer’s disease (AD). We previously reported that neuron-derived exosomes promote Aβ clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulated by ceramid...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Yuyama, Kohei, Takahashi, Kaori, Usuki, Seigo, Mikami, Daisuke, Sun, Hui, Hanamatsu, Hisatoshi, Furukawa, Junichi, Mukai, Katsuyuki, Igarashi, Yasuyuki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856149/
https://ncbi.nlm.nih.gov/pubmed/31727994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53394-w
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