Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers

IDH1/2 mutations are early drivers present in diverse human cancer types arising in various tissue sites. IDH1/2 mutation is known to induce a global hypermethylator phenotype. However, the effects on DNA methylation across IDH mutant cancers and functionally different genome regions, remain unknown...

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Udgivet i:Sci Rep
Main Authors: Bledea, Ramona, Vasudevaraja, Varshini, Patel, Seema, Stafford, James, Serrano, Jonathan, Esposito, Gianna, Tredwin, Lilian M., Goodman, Nina, Kloetgen, Andreas, Golfinos, John G., Zagzag, David, Weigelt, Britta, Iafrate, A. John, Sulman, Erik P., Chi, Andrew S., Dogan, Snjezana, Reis-Filho, Jorge S., Chiang, Sarah, Placantonakis, Dimitris, Tsirigos, Aristotelis, Snuderl, Matija
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856069/
https://ncbi.nlm.nih.gov/pubmed/31727977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53262-7
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