Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids. The exact modulatory effect of anionic phospholipids in pLGICs and the mechanism of this effect are not well understood. Using nati...

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Vydáno v:eLife
Hlavní autoři: Tong, Ailing, Petroff, John T, Hsu, Fong-Fu, Schmidpeter, Philipp AM, Nimigean, Crina M, Sharp, Liam, Brannigan, Grace, Cheng, Wayland WL
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Structural Biology and Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855808/
https://ncbi.nlm.nih.gov/pubmed/31724949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50766
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