Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids. The exact modulatory effect of anionic phospholipids in pLGICs and the mechanism of this effect are not well understood. Using nati...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Tong, Ailing, Petroff, John T, Hsu, Fong-Fu, Schmidpeter, Philipp AM, Nimigean, Crina M, Sharp, Liam, Brannigan, Grace, Cheng, Wayland WL
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855808/
https://ncbi.nlm.nih.gov/pubmed/31724949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50766
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