N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate in AD Tau inc...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Schlegel, Kerstin, Awwad, Khader, Heym, Roland G., Holzinger, David, Doell, Annika, Barghorn, Stefan, Jahn, Thomas R., Klein, Corinna, Mordashova, Yulia, Schulz, Michael, Gasparini, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854719/
https://ncbi.nlm.nih.gov/pubmed/31722749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0831-2
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