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Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers

Aggregation of highly phosphorylated tau is a hallmark of Alzheimer’s disease and other tauopathies. Nevertheless, animal models demonstrate that tau-mediated dysfunction/toxicity may not require large tau aggregates but instead may be caused by soluble hyper-phosphorylated tau or by small tau oligo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cowan, Catherine M., Quraishe, Shmma, Hands, Sarah, Sealey, Megan, Mahajan, Sumeet, Allan, Douglas W., Mudher, Amritpal
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660438/
https://ncbi.nlm.nih.gov/pubmed/26608845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17191
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