Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway that modulates cellular redox homeostasis via the regeneration of NADPH. G6PD-deficient cells have a reduced ability to induce the innate immune response, thus increasing host susceptibility to path...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Yen, Wei-Chen, Wu, Yi-Hsuan, Wu, Chih-Ching, Lin, Hsin-Ru, Stern, Arnold, Chen, Shih-Hsiang, Shu, Jwu-Ching, Tsun-Yee Chiu, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854078/
https://ncbi.nlm.nih.gov/pubmed/31707353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101363
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